The 51st Annual Meeting of the European Society of Dermatological Research (ESDR) took place from September 28 to October 1, 2022, in Amsterdam, Netherlands. This prestigious event brought together leading dermatology researchers, clinicians, and industry experts to discuss advancements in skin science, immune-dermatology, and translational research. Presentations covered novel therapies, AI applications in dermatology, and breakthroughs in inflammatory skin diseases.